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- Marzia Angelo, Bernhard Gutmann, Michele Adami, Bernd Zagler, Anton Zelger, Christoph Pechlaner, and Christian J Wiedermann.
- 2nd Division of Internal Medicine, Department of Internal Medicine, Central Hospital of Bolzano, Bolzano, Italy. marzia.angelo@asbz.it
- Thromb J. 2007 Jan 10; 5: 1.
AbstractRecommendations for urgent reversal of oral anticoagulation with vitamin K1 antagonists are largely derived from case series employing empirical dosing regimens with vitamin K1 and prothrombin complex concentrates. Data on the use of prothrombin complex concentrates in this indication are scarce in the elderly who are at high risk of both hemorrhagic and thrombotic complications. The two cases presented here describe patients older than 75 years who underwent rapid International Normalized Ratio (INR) reversal with prothrombin complex concentrates for surgical treatment of a bleeding ruptured spleen and for emergency surgery of a dissecting aorta. Both patients had their INRs rapidly corrected to
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