• Xiaohu Li, Hongmin Shu, Yifei Zhang, Xiaoshu Li, Jian Song, Junhua Du, Yinfeng Qian, Bin Liu, and Yongqiang Yu.
• Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
• Oncotarget. 2018 Apr 13; 9 (28): 20103-20111.

PurposeTo prospectively determine the diagnostic performance of low-dose CT (LDCT) with adaptive statistical iterative reconstruction (ASIR) technique for the detection of urinary stone disease.ResultsThe average DLP and ED was 408.16 ± 119.04 mGy and 6.12 ± 1.79 mSv in CDCT, and 138.19 ± 76.87 mGy and 2.07 ± 1.15 mSv in LDCT, respectively. The dose reduction rate of LDCT was nearly 66.1% for both DLP and ED (P < 0.05). LDCT-80% ASIR images showed great image quality (mean score = 4.09), which was similar to CDCT-FBP images (mean score = 4.17) (P > 0.05), but higher than LDCT-FBP images (mean score = 2.77) (P < 0.05).Materials And Methods70 consetutive patients with clinically suspected urolithiasis underwent non-enhanced CT. Followed by both conventional-dose CT (CDCT) and low-dose CT (LDCT) scans. Automatic tube current modulation (ATCM) scanning was used, with a noise index setting of 13 in CDCT and 25 in LDCT. Reconstructions were performed with filtered back projection (FBP) and different settings of adaptive statistical iterative reconstruction [ASIR(40%, 60%, 80%)]. Urinary calculi (size, location, number), image quality (scale 1-5), image noise (scale 1-3) and diagnostic confidence levels (scale 1-3) were evaluated and measured by two radiologists independently. Radiation dose was recorded by calculating dose length product (DLP) and effective dose (ED). Statistical analyses included Mann-Whitney U test and Paired t tests.ConclusionsLDCT with ASIR can reduce the radiation dose while maintain relatively high image quality in the diagnosis of urinary stone diseases.

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