• Liang Wang, Zhiyong Liu, Zhe Dong, Jieyi Pan, and Xiaochun Ma.
• Department of Intensive Care Medicine, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, China.
• J. Surg. Res. 2016 May 1; 202 (1): 147-54.

BackgroundThis study was conducted to investigate whether Xuebijing injection can rectify the dysfunction of microcirculation in septic shock and assessed the microcirculatory parameters directly via orthogonal polarization spectral and software AVA 3.0.Material And MethodsAnesthetized and mechanically ventilated beagle dogs were modeled for septic shock via lipopolysaccharide (LPS) intravenous injection. They were divided randomly into four groups, control group accepted operation only for jejunostomy and cystostomy; LPS group accepted operation and LPS intravenous injection; saline group accepted operation, LPS intravenous injection, and saline resuscitation; XBJ group accepted operation, LPS intravenous injection, saline resuscitation, and Xuebijing injection infusion. The MAP was recorded via right femoral artery catheterization, at the same time, the blood gas analysis was taken via that pathway at the set time points. ScvO2 was obtained via right jugular vein catheterization at the related time points. Microcirculatory parameters were recorded by orthogonal polarization spectral via the jejunum stoma, and the microcirculation image was analyzed via the software AVA 3.0 later.ResultsXuebijing injection improved microcirculation of the jejunum villus in canine model of septic shock induced by endotoxin, especially for the proportion of perfused vessels.ConclusionsBased on the adequate fluid resuscitation, Xuebijing injection plays a helpful role of improving microcirculation in septic shock.Copyright © 2016 Elsevier Inc. All rights reserved.

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