• Br J Gen Pract · Jan 2022

    Factors affecting the decision to investigate older adults with potential cancer symptoms: a systematic review.

    • Daniel Jones, Erica Di Martino, Stephen H Bradley, Blessing Essang, Scott Hemphill, Judy M Wright, Cristina Renzi, Claire Surr, Andrew Clegg, Niek De Wit, and Richard Neal.
    • Leeds Institute of Health Sciences, University of Leeds, Leeds, UK.
    • Br J Gen Pract. 2022 Jan 1; 72 (714): e1e10e1-e10.

    BackgroundOlder age and frailty increase the risk of morbidity and mortality from cancer surgery and intolerance of chemotherapy and radiotherapy. The effect of old age on diagnostic intervals is unknown; however, older adults need a balanced approach to the diagnosis and management of cancer symptoms, considering the benefits of early diagnosis, patient preferences, and the likely prognosis of a cancer.AimTo examine the association between older age and diagnostic processes for cancer, and the specific factors that affect diagnosis.Design And SettingA systematic literature review.MethodElectronic databases were searched for studies of patients aged >65 years presenting with cancer symptoms to primary care considering diagnostic decisions. Studies were analysed using thematic synthesis and according to the Synthesis Without Meta-analysis guidelines.ResultsData from 54 studies with 230 729 participants were included. The majority of studies suggested an association between increasing age and prolonged diagnostic interval or deferral of a decision to investigate cancer symptoms. Thematic synthesis highlighted three important factors that resulted in uncertainty in decisions involving older adults: presence of frailty, comorbidities, and cognitive impairment. Data suggested patients wished to be involved in decision making, but the presence of cognitive impairment and the need for additional time within a consultation were significant barriers.ConclusionThis systematic review has highlighted uncertainty in the management of older adults with cancer symptoms. Patients and their family wished to be involved in these decisions. Given the uncertainty regarding optimum management of this group of patients, a shared decision-making approach is important.© The Authors.

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