• Internal medicine journal · Nov 2021

    Outcomes of non-myeloablative allogeneic stem cell transplant in older patients with acute myeloid leukaemia in first remission.

    • Phillip C Nguyen, Kate Manos, Chun Y Fong, Anthony P Schwarer, Ing S Tiong, Andrew H Wei, David Kliman, and David J Curtis.
    • Department of Clinical Haematology, Alfred Health, Melbourne, Victoria, Australia.
    • Intern Med J. 2021 Nov 1; 51 (11): 1954-1958.

    AbstractThe benefits of non-myeloablative stem cell transplant in older patients with acute myeloid leukaemia are unclear. We compare the long-term outcomes of this regimen in those aged 55-65 years in first remission with a chemotherapy only cohort that achieved durable morphologic remission. Five-year overall survival was similar (32% vs 33%, P = 0.90), as was relapse-free survival (23% vs 20%, P = 0.37). There was a trend for decreased relapse that was balanced against increased non-relapse mortality with transplantation.© 2021 Royal Australasian College of Physicians.

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