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Internal medicine journal · Nov 2021
Oromandibular parafunction in chronic graft-versus-host disease: novel association and treatment approach.
- Purwa Joshi, Lynette Kiers, Andrew Evans, David Ritchie, Jeff Szer, and Belinda Cruse.
- Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
- Intern Med J. 2021 Nov 1; 51 (11): 1950-1953.
AbstractChronic graft-versus-host disease (cGVHD) complicating allogeneic haemopoietic stem cell transplantation rarely involves the nervous system; oromandibular parafunction has not been previously reported. We describe five patients with cGVHD, presenting with bruxism, limitation of mouth opening, jaw locking, pain and masseter hypertrophy. Pathophysiological mechanisms are discussed. Targeted botulinum toxin injections were an effective treatment with minimal side-effects.© 2021 Royal Australasian College of Physicians.
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