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Int. J. Biochem. Cell Biol. · Jul 2014
ReviewMolecular modelling approaches for cystic fibrosis transmembrane conductance regulator studies.
- Norbert Odolczyk and Piotr Zielenkiewicz.
- Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02-106 Warszawa, Poland.
- Int. J. Biochem. Cell Biol. 2014 Jul 1; 52: 39-46.
AbstractCystic fibrosis (CF) is one of the most common genetic disorders, caused by loss of function mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein. CFTR is a member of ATP-binding cassette (ABC) transporters superfamily and functions as an ATP-gated anion channel. This review summarises the vast majority of the efforts which utilised molecular modelling approaches to gain insight into the various aspects of CFTR protein, related to its structure, dynamic properties, function and interactions with other protein partners, or drug-like compounds, with emphasis to its relation to CF disease.Copyright © 2014 Elsevier Ltd. All rights reserved.
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