• Hillary Nascimento Coletro, Amanda Popolino Diniz, Nathália Sernizon Guimarães, Júlia Cristina Cardoso Carraro, Raquel de Deus Mendonça, and Adriana Lúcia Meireles.
• MSc. Doctoral Student, Postgraduate Program on Health and Nutrition, School of Nutrition, Universidade Federal de Ouro Preto (UFOP), Ouro Preto (MG), Brazil; Doctoral Student, Grupo de Pesquisa e Ensino em Nutrição e Saúde Coletiva (GPENSC), Ouro Preto (MG), Brazil.
• Sao Paulo Med J. 2021 Jan 1; 139 (6): 615623615-623.

BackgroundRheumatic diseases (RDs) are a group of pathological conditions characterized by inflammation and functional disability. There is evidence suggesting that regular consumption of polyphenols has therapeutic effects capable of relieving RD symptoms.ObjectiveTo synthesize data from randomized controlled trials on administration of polyphenols and their effects on RD activity.Design And SettingSystematic review conducted at Universidade Federal de Ouro Preto, Minas Gerais, Brazil.MethodsA systematic search was conducted in the databases PubMed (Medline), LILACS (BVS), IBECS (BVS), CUMED (BVS), BINACIS (BVS), EMBASE, Web of Science and Cochrane Library and in the grey literature. The present study followed a PRISMA-P checklist.ResultsIn total, 646 articles were considered potentially eligible, of which 33 were then subjected to complete reading. Out of these, 17 randomized controlled trials articles were selected to form the final sample. Among these 17 articles, 64.71% assessed osteoarthritis (n = 11), 23.53% rheumatoid arthritis (n = 4), 5.88% rheumatoid arthritis and fibromyalgia (n = 1) and 5.88% osteoarthritis and rheumatoid (n = 1). Intake of polyphenol showed positive effects in most of the studies assessed (94.12%): it improved pain (64.70%) and inflammation (58.82%).ConclusionPolyphenols are potential allies for treating RD activity. However, the range of polyphenol sources administered was a limitation of this review, as also was the lack of information about the methodological characteristics of the studies evaluated. Thus, further primary studies are needed in order to evaluate the effects of polyphenol consumption for reducing RD activity.Systematic Review RegisterPROSPERO - CRD42020145349.

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