• Filippo Patrucco, Giuseppe Failla, Giovanni Ferrari, Thomas Galasso, Piero Candoli, Michele Mondoni, Roberto Piro, Nicola C Facciolongo, Teresa Renda, Mario Salio, Raffaele Scala, Paolo Solidoro, Alessio Mattei, Paolo Donato, Rosanna Vaschetto, Piero E Balbo, and Interventional Pneumology and Lung Transplant Associazione Italiana Pneumologi Ospedalieri - Italian Thoracic Society (AIPO-ITS) study group.
• Respiratory Diseases Unit, Medical Department, AOU Maggiore della Carità, Novara, Italy - filippo.patrucco@maggioreosp.novara.it.
• Panminerva Med. 2021 Oct 4.

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has changed bronchoscopy practices worldwide. Bronchoscopy is a high-risk aerosol-generating procedure with a potential for direct SARS-CoV-2 exposure and hospital-acquired infection. Current guidelines about personal protective equipment and environment considerations represent key competencies to minimize droplets dispersion and reduce the risk of transmission. Different measures should be put in field based on setting, patient's clinical characteristics, urgency and indications of bronchoscopy. The use of this technique in SARS-CoV-2 patients is reported primarily for removal of airway plugs and for obtaining microbiological culture samples. In mechanically ventilated patients with SARS-CoV-2, bronchoscopy is commonly used to manage complications such as hemoptysis, atelectasis or lung collapse when prone positioning, physiotherapy or recruitment maneuvers have failed. Further indications are represented by assistance during percutaneous tracheostomy. Continuous positive airway pressure, non-invasive ventilation support and high flow nasal cannula oxygen are frequently used in patient affected by Coronavirus Disease-2019 (COVID-19): management of patients' airways and ventilation strategies differs from bronchoscopy indications, patient's clinical status and in course or required ventilatory support. Sedation is usually administered by the pulmonologist (performing the bronchoscopy) or by the anesthetist depending on the complexity of the procedure and the level of sedation required. Finally, elective bronchoscopy for diagnostic indications during COVID-19 pandemic should be carried on respecting rigid standards which allow to minimize potential viral transmission, independently from patient's COVID-19 status. This narrative review aims to evaluate the indications, procedural measures and ventilatory strategies of bronchoscopy performed in different settings during COVID-19 pandemic.

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