• Sonja E Leonhard, Melissa R Mandarakas, de Assis Aquino GondimFranciscoFHospital Universitário Walter Cantidio, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Kathleen Bateman, Maria L Brito Ferreira, David R Cornblath, Pieter A Van Doorn, Mario E Dourado, HughesRichard A CRACUCLQueen Square Institute of Neurology, London, United Kingdom., Badrul Islam, Susumu Kusunoki, Carlos A Pardo, Ricardo Reisin, James J Sejvar, Nortina Shahrizaila, Cristiane Soares, Thirugnanam Umapathi, Yuzhong Wang, Eppie M Yiu, Hugh J Willison, and Bart C Jacobs.
• Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
• Medicina (B Aires). 2021 Jan 1; 81 (5): 817836817-836.

AbstractGuillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and in 2015 in Latin America. Diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous, and no international clinical guidelines are currently available. To support clinicians, especially in the context of an outbreak, we have developed a globally applicable guideline for the diagnosis and management of GBS. The guideline is based on current literature and expert consensus, and has a ten-step structure to facilitate its use in clinical practice. We first provide an introduction to the diagnostic criteria, clinical variants and differential diagnoses of GBS. The ten steps then cover early recognition and diagnosis of GBS, admission to the intensive care unit, treatment indication and selection, monitoring and treatment of disease progression, prediction of clinical course and outcome, and management of complications and sequelae.

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