• Am. J. Respir. Crit. Care Med. · Mar 2022

    Review

    Management of Advanced Pulmonary Sarcoidosis.

    • Rohit Gupta, Marc A Judson, and Robert P Baughman.
    • Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.
    • Am. J. Respir. Crit. Care Med. 2022 Mar 1; 205 (5): 495-506.

    AbstractThe term "advanced sarcoidosis" is used for forms of sarcoidosis with a significant risk of loss of organ function or death. Advanced sarcoidosis often involves the lung and is described as "advanced pulmonary sarcoidosis" (APS), which includes advanced pulmonary fibrosis, associated complications such as bronchiectasis and infections, and pulmonary hypertension. Although APS affects a small proportion of patients with sarcoidosis, it is the leading cause of poor outcomes, including death. Here we review the major patterns of APS with a focus on the current management as well as potential approaches for improved outcomes for this most serious sarcoidosis phenotype.

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