• Crit Care Explor · Nov 2020

    Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation.

    • Heike Hofmann-Winkler, Onnen Moerer, Sabine Alt-Epping, Anselm Bräuer, Benedikt Büttner, Martin Müller, Torben Fricke, Julian Grundmann, Lars-Olav Harnisch, Daniel Heise, Andrea Kernchen, Meike Pressler, Caspar Stephani, Björn Tampe, Artur Kaul, Sabine Gärtner, Stefanie Kramer, Stefan Pöhlmann, and Martin Sebastian Winkler.
    • Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
    • Crit Care Explor. 2020 Nov 1; 2 (11): e0284.

    AbstractSevere acute respiratory syndrome coronavirus 2 cell entry depends on angiotensin-converting enzyme 2 and transmembrane serine protease 2 and is blocked in cell culture by camostat mesylate, a clinically proven protease inhibitor. Whether camostat mesylate is able to lower disease burden in coronavirus disease 2019 sepsis is currently unknown.Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

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