• Iasmin Dos Santos Barreto, Raquel Oliveira Dos Santos, Raquel Rocha, Claudineia de Souza, Naiade Almeida, Luiza Valois Vieira, Rafael Leiróz, Manoel Sarno, Carla Daltro, and Helma Pinchemel Cotrim.
• Universidade Federal da Bahia, Escola de Nutrição - Salvador (BA), Brazil.
• Rev Assoc Med Bras (1992). 2021 Sep 1; 67 (9): 1233-1239.

ObjectiveTo evaluate the association between muscle mass depletion and compromising of the cell membrane integrity and clinical-anthropometric characteristics in patients with nonalcoholic fatty liver disease.MethodsThis observational study evaluated waist circumference, body mass index, and waist-to-height ratio in patients with nonalcoholic fatty liver disease. Skeletal mass index corrected by weight and impairment of cell membrane integrity were assessed using bioelectrical impedance analysis.ResultsIn 56 patients, muscle mass depletion was observed in 62.5% and cell membrane impairment in 28.6%. The metabolic syndrome and elevated aspartate aminotransferase were the only clinical factors associated with mass depletion (p<0.05). The linear regression analysis showed association between skeletal mass index and waist-to-height ratio and waist circumference, after adjustments (p<0.05). The phase angle value was not different between those with and without mass depletion, and also it did not have correlation with skeletal mass index and clinical parameters (p>0.05).ConclusionsThe prevalence of mass depletion and cell membrane impairment was higher in patients with nonalcoholic fatty liver disease. The muscle mass depletion was associated with central obesity, aspartate aminotransferase elevated, and metabolic syndrome; however, the phase angle is not associated with clinical and anthropometric data.

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