• J. Alzheimers Dis. · Jan 2016

    Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation.

    • María Carmona-Iragui, Ana Fernández-Arcos, Daniel Alcolea, Fabrizio Piazza, Estrella Morenas-Rodriguez, Sofía Antón-Aguirre, Isabel Sala, Jordi Clarimon, Oriol Dols-Icardo, Valle Camacho, Frederic Sampedro, Josep Munuera, Fidel Nuñez-Marin, Alberto Lleó, Juan Fortea, Beatriz Gómez-Ansón, and Rafael Blesa.
    • Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
    • J. Alzheimers Dis. 2016 Jan 1; 50 (1): 1-7.

    AbstractWe report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreased Aβ40 and Aβ42. After treatment, focal symptomatology disappeared, and WML and anti-Aβ autoantibodies decreased. The APOEɛ4 allele was overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.

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