-
Eur. J. Clin. Microbiol. Infect. Dis. · Jul 1990
ReviewThe design of clinical trials with antibiotics.
- S R Norrby.
- Department of Infectious Diseases, Lund University Hospital, Sweden.
- Eur. J. Clin. Microbiol. Infect. Dis. 1990 Jul 1; 9 (7): 523-9.
AbstractClinical trials to test antibiotics are normally of a less than satisfactory quality. Examples of common errors in the design and execution of trials with antibiotics are inclusion of too few patients to allow conclusions to be drawn, open uncontrolled design leading to a risk of considerable investigator bias, and inclusion of heterogeneous patient samples. This article suggests minimum requirements for antibiotic studies. Guidelines for such trials are needed and should have the widest possible international application in order to permit studies involving centres in various countries and to reduce the costs for development of new drugs.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..