• Connecticut medicine · Oct 1993

    Case Reports

    Acute tumor lysis syndrome complicating fludarabine treatment of prolymphocytic leukemia.

    • L M Cannon, L Spilove, R Rhodes, H Garfinkel, and J Pezzimenti.
    • Department of Medicine, Danbury Hospital, Yale University School of Medicine.
    • Conn Med. 1993 Oct 1; 57 (10): 651-4.

    AbstractTumor lysis syndrome rarely occurs during chemotherapy treatment of indolent lymphoid tumors. This report describes for the first time a case of acute tumor lysis syndrome complicating fludarabine treatment of prolymphocytic leukemia. In this particular case the patient had an unexpectedly rapid response to fludarabine 15 days after initiation of the first chemotherapy cycle, which was subsequently complicated by the development of tumor lysis syndrome. Until more data are known concerning fludarabine treatment of prolymphocytic leukemia, cautious monitoring of patients treated with fludarabine should be undertaken, even after completion of the chemotherapy course.

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