• Marie H Gedde, Bettina S Husebo, Janne Mannseth, Reidun L S Kjome, Mala Naik, and Line I Berge.
• Centre for Elderly and Nursing Home Medicine, Department of Global Public Health and Primary Care, Faculty of Medicine, University of Bergen, Bergen, Norway; Haraldsplass Deaconess Hospital, Bergen, Norway. Electronic address: marie.gedde@uib.no.
• Am J Geriatr Psychiatry. 2021 Mar 1; 29 (3): 304-315.

ObjectiveTo investigate the impact of medication reviews using collegial mentoring and systematic clinical evaluation on psychotropic prescriptions, behavioral and psychological symptoms of dementia (BPSD), and activities of daily living (ADL).DesignFour-month multicenter, multicomponent, cluster-randomized, single-blinded controlled trial.SettingThirty-three Norwegian nursing homes including 67 nursing home wards (clusters).ParticipantsA total of 723 enrolled patients, of which 428 participated in the study; 217 were randomized to the intervention and 211 to care as usual (control).InterventionThe COSMOS intervention consisted of Communication, Systematic pain management, Medication reviews, Organization of activities, and Safety. During medication review, the nursing home physician evaluated treatment with colleagues systematically using the results from validated clinical assessments.MeasurementsMean changes from baseline to month 4 in the number of prescribed psychotropic drugs (antipsychotics, anxiolytics, hypnotics or sedatives, antidepressants, and antidementia drugs); Neuropsychiatric Inventory Nursing Home Version (NPI-NH) and Cornell Scale of Depression in Dementia (CSDD); Lawton and Brody's Physical Self Maintenance Scale (PSMS).ResultsCompared to control, the mean change in prescribed psychotropic drugs was reduced both in total and regular number, while mean changes in NPI-NH and CSDD scores did not differ between the groups. Mean change in PSMS showed improvement in the intervention group, and deterioration in the control group.ConclusionMedication reviews using collegial mentoring and systematic clinical evaluation led to safe deprescribing, as the reductions in psychotropic drug use did not negatively affect BPSD, while ADL improved.Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

23 keywords...

hide…