• Alberto C Helito, Livia Lindoso, Sofia M Sieczkowska, Camilla Astley, Ligia B Queiroz, Natalia Rose, Claudia Renata P Santos, Thalis Bolzan, Rita María I A Peralta, Ruth R Franco, Louise Cominato, PereiraRosa Maria RRMR0000-0002-3723-5028Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., Uenis Tannuri, CamposLucia Maria ALMA0000-0001-9653-0468Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., Benito Lourenço, Ricardo K Toma, Karina Medeiros, Andréia Watanabe, Patricia Moreno Grangeiro, Sylvia C Farhat, Caio B Casella, Guilherme V Polanczyk, Bruno Gualano, Clovis A Silva, HC-FMUSP Adolescent COVID-19 Study Group, SallumAdriana M EAMEHospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, BR., Amanda Y Iraha, Bianca P Ihara, Bruna C Mazzolani, Claudia A Martinez, Claudia A A Strabelli, Claudia B Fonseca, Dandara C C Lima, Debora N D Setoue, Deborah F P Roz, Fabiana I Smaira, Hamilton Roschel, Helena T Miyatani, Isabela G Marques, Jane Oba, Juliana C O Ferreira, Juliana R Simon, Katia Kozu, Ligia P Saccani, Lorena V M Martiniano, Luana C A Miranda, Luiz E V Silva, Moisés F Laurentino, Nadia E Aikawa, Neusa K Sakita, Nicolas Y Tanigava, Paulo R A Pereira, Patrícia Palmeira, Simone S Angelo, Sofia S M Lavorato, Tamires M Bernardes, Tathiane C Franco, Vivianne S L Viana, Vera P M F R Barros, and Yingying Zheng.
• Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
• Clinics (Sao Paulo). 2021 Jan 1; 76: e3501e3501.

ObjectiveTo assess the possible factors that influence sleep quality in adolescents with and without chronic immunosuppressive conditions quarantined during the coronavirus disease 2019 (COVID-19) pandemic.MethodsThis cross-sectional study included 305 adolescents with chronic immunocompromised conditions and 82 healthy adolescents. Online surveys were completed, which included questions on socio-demographic data and self-rated healthcare routine during COVID-19 quarantine and the following validated questionnaires: the Pittsburgh Sleep Quality Index (PSQI), Pediatric Quality of Life Inventory 4.0 (PedsQL4.0), and Pediatric Outcome Data Collection Instrument (PODCI).ResultsThe median current age [14 (10-18) vs. 15 (10-18) years, p=0.847] and frequency of female sex (62% vs. 58%, p=0.571) were similar in adolescents with chronic conditions compared with healthy adolescents. The frequency of poor sleep quality was similar in both groups (38% vs. 48%, p=0.118). Logistic regression analysis, including both healthy adolescents and adolescents with chronic conditions (n=387), demonstrated that self-reported increase in screen time (odds ratio [OR] 3.0; 95% confidence interval [CI] 1.3-6.8; p=0.008) and intrafamilial violence report (OR 2.1; 95% CI 1.2-3.5; p=0.008) were independently associated with poor sleep quality in these adolescents. However, the PODCI global function score was associated with a lower OR for poor sleep quality (OR 0.97; 95% CI 0.94-0.99; p=0.001). Further logistic regression, including only adolescents with chronic conditions (n=305), demonstrated that self-reported increase in screen time (OR 3.1; 95% CI 1.4-6.8; p=0.006) and intrafamilial violence report (OR 2.0; 95% CI 1.2-3.4; p=0.011) remained independently associated with poor quality of sleep, whereas a lower PODCI global function score was associated with a lower OR for sleep quality (OR 0.96; 95% CI 0.94-0.98; p<0.001).ConclusionSelf-reported increases in screen time and intrafamilial violence report impacted sleep quality in both healthy adolescents and those with chronic conditions. Decreased health-related quality of life was observed in adolescents with poor sleep quality.

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