• Int. J. Legal Med. · Jan 2000

    Case Reports

    The distribution of laudanosine in tissues after death from atracurium injection.

    • P Kintz, A Tracqui, and B Ludes.
    • Institut de Médecine Légale, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg, France. pascal.kintz@wanadoo.fr
    • Int. J. Legal Med. 2000 Jan 1; 114 (1-2): 93-5.

    AbstractA case is presented involving an acute fatality resulting from self-administration of atracurium, a muscle relaxant by a 45-year-old nurse. In the body, atracurium undergoes a spontaneous non-enzymatic degradation to laudanosine and an acrylate moiety. Laudanosine was quantified using gas chromatography coupled to mass spectrometry after extraction with chloroform-isopropanol-n-heptane (50:17:33 v/v) at pH 9.5 and separation on a HP5-MS capillary column. Laudanosine was subject to postmortem redistribution due to release from drug-rich tissues such as the lung and heart. The heart blood (917 ng/ml) to peripheral blood (390 ng/ml) ratio was 2.4. No other drugs, including ethanol were detected.

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