• Clin. Pharmacol. Ther. · Sep 2016

    Implications of Programmed Cell Death 1 Ligand 1 Heterogeneity in the Selection of Patients With Non-Small Cell Lung Cancer to Receive Immunotherapy.

    • A S Mansfield and H Dong.
    • Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
    • Clin. Pharmacol. Ther. 2016 Sep 1; 100 (3): 220-2.

    AbstractThe use of programmed cell death 1 ligand 1 (PD-L1) as a predictive biomarker to select patients to receive programmed cell death 1 (PD-1) or PD-L1 inhibitors in non-small cell lung cancer (NSCLC) is limited by the definitions of positivity, interassay agreement, and intra- and intertumoral heterogeneity of expression. Although PD-L1 expression enriches for responses, the lack of expression does not exclude clinical benefit.© 2016 American Society for Clinical Pharmacology and Therapeutics.

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