• Internal medicine · Jun 2022

    Case Reports

    Persistent Expression of Recipient-type ABH Antigen after ABO-Incompatible Allogeneic Hematopoietic Stem Cell Transplantation.

    • Yukiko Misaki, Shinichi Kako, Shunto Kawamura, Junko Takeshita, Nozomu Yoshino, Kazuki Yoshimura, Ayumi Gomyo, Yu Akahoshi, Masaharu Tamaki, Machiko Kusuda, Kazuaki Kameda, Hidenori Wada, Koji Kawamura, Miki Sato, Kiriko Terasako-Saito, Shun-Ichi Kimura, Hideki Nakasone, Koji Kishino, Kazuo Muroi, and Yoshinobu Kanda.
    • Division of Hematology, Jichi Medical University Saitama Medical Center, Japan.
    • Intern. Med. 2022 Jun 15; 61 (12): 1887-1890.

    AbstractIn general, the recipient's ABO blood type changes to the donor's ABO blood type after ABO-incompatible allogeneic hematopoietic stem cell transplantation (HSCT). However, we experienced a 26-year-old male with acute myelogenous leukemia (AML) who underwent ABO-incompatible HSCT twice and persistently showed his original blood type even after demonstrating complete donor-type chimerism. Based on the results of various examinations, we considered that the antigen of the recipient's original blood type persistently synthesized in the recipient's non-hematopoietic organs was secreted and adsorbed on the surface of donor-derived RBCs. We should therefore perform detailed examinations to determine the precise blood type after ABO-incompatible HSCT.

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