• Hans-Christoph Diener, Tobias Kurth, and Dagny Holle.
• Department of Neurology and Headache Center, University Hospital Essen, Germany hans.diener@uni-duisburg-essen.de.
• Cephalalgia. 2015 Feb 1; 35 (2): 140-5.

BackgroundNumerous studies have described a relationship between migraine and stroke, and there is emerging evidence that migraine is also associated with cardiovascular disease. The combination of migraine and both cerebrovascular and cardiovascular disease has implications for therapy.MethodsWe conducted a review of the modifications in medical therapy in patients with comorbid migraine and cardio- and cerebrovascular disorders based on publications from the last 15 years.ResultsSome drugs are contraindicated to treat migraine attacks (ergots, triptans) or for migraine prevention in patients after transient ischemic attack (TIA)/ischemic stroke. Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated in patients with cerebral bleeding. Some drugs for the treatment of acute migraine attacks are contraindicated in patients with symptomatic coronary heart disease.ConclusionsGiven the large number of patients with comorbid migraine and cardiovascular as well as cerebrovascular disease, there is an unmet need to treat these patients.© International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

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