• Hans-Peter Brunner-La Rocca, Gerard C Linssen, Frank J Smeele, Annemarie A van Drimmelen, Henk-Jan Schaafsma, Paul H Westendorp, Philip C Rademaker, Hendrik J van de Kamp, Arno W Hoes, Jasper J Brugts, and CHECK-HF Investigators.
• Department of Cardiology, Maastricht University Medical Center, Maastricht, Limburg, the Netherlands. Electronic address: hp.brunnerlarocca@mumc.nl.
• JACC Heart Fail. 2019 Jan 1; 7 (1): 13-21.

ObjectivesThis study investigated adherence to drug therapy guidelines in heart failure (HF) with reduced left-ventricular ejection fraction (LVEF) of <40% (heart failure with reduced ejection fraction [HFrEF]), in which evidence-based treatment has been established.BackgroundDespite previous surveys of HF, important uncertainties remain regarding guideline adherence in a representative real-world population.MethodsA cross-sectional registry in 34 Dutch HF outpatient clinics that included 10,910 patients with the diagnosis of HF was examined. Of that number, 8,360 patients had LVEF <50% (72 ± 12 years of age; 64% male) and were divided into HFrEF (n = 5,701), HF with mid-range LVEF (HFmrEF) with LVEF 40% to 49% (n = 1,574), and those with semiquantitatively measured LVEF but <50% (n = 1,085).ResultsIn the HFrEF group, 81% of the patients were treated with loop diuretics, 84% with renin-angiotensin-system (RAS) inhibitors, 86% with β-blockers, 56% with mineralocorticoid-receptor antagonists (MRA), and 5% with If-channel inhibition. Differences in medication use were minor among the 3 groups but were significant among centers. Inability to tolerate the medications was recorded in 9.4% patients taking RAS inhibitors, 3.3% taking β-blockers, and 5.4% taking MRAs. Median loop diuretic dose was 40 mg of furosemide equivalent, RAS inhibitor dose 50% of target, β-blocker dose 25% of target, and MRA dose 12.5 mg of spironolactone equivalent. Elderly patients were treated predominantly with diuretics and less often with RAS inhibitors, β-blockers, and MRAs.ConclusionsThis large contemporary HF registry showed a relatively high use of evidence-based treatment, particularly in younger patients. However, the average dose of evidence-based medication was still lower than recommended by guidelines. Furthermore, the more recently introduced If-channel inhibition has hardly been adopted. There is ample room for improvement of HFrEF therapy, even more than 25 years after convincing evidence that HFrEF treatment leads to better outcome.Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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