• Hitoshi Ojima, Hiroyuki Kuwano, Hiroyuki Kato, Tatsuya Miyazaki, Masanobu Nakajima, Makoto Sohda, and Katsuhiko Tsukada.
• Department of General Surgical Science, Gunma University Faculty of Medicine, Maebashi, Japan. hojima@showa.gunma-u.ac.jp
• Hepato Gastroenterol. 2007 Jan 1; 54 (73): 111-5.

Background/AimsPostoperative pulmonary complications are often fatal in patients with esophageal cancer. The aim of this study was to clarify the association between cytokines and temporary ventilation during one-lung ventilation.MethodologySerum and BALF IL-6, 8 were measured in 39 patients with esophageal cancer, and the relationship between cytokine response and temporary ventilation during one-lung ventilation in esophagectomy was examined.ResultsPulmonary complications did not occur in our patients. Serum IL-6 levels were significantly increased in the high one-lung ventilation ratio and long-term one-lung ventilation groups. Serum IL-6 levels in the one or more times ventilation group during one-lung ventilation were significantly low compared to the no-ventilation group. There were no significant differences in serum IL-8 and BALF IL-6, 8 levels.ConclusionsOur results indicate that it is important to ventilate one or more times during one-lung ventilation in order to reduce postoperative pulmonary complications.

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