• Anne-Marie Wegeberg, Davide Bertoli, Niels Ejskjaer, Birgitte Brock, Asbjørn Mohr Drewes, and Christina Brock.
• Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark.
• J. Intern. Med. 2022 Apr 1; 291 (4): 505-512.

BackgroundGastrointestinal dysmotility may exist without concomitant symptoms. We hypothesize that asymptomatic individuals with diabetes have altered gastrointestinal function associated with age, cardiac vagal tone and glycaemic control.MethodsOne hundred fifty-four asymptomatic participants (61 with type 1 diabetes (T1D), 70 type 2 diabetes (T2D) and 23 healthy volunteers (HV)) underwent wireless motility capsule investigation. Transit times, motility indices and pH were retrieved. Age, cardiac vagal tone, glucose and haemoglobin A1c levels were collected.ResultsIn T1D, prolongation of colonic (p = 0.03) and whole-gut transit times (p = 0.04) were shown. Transpyloric pH rise was decreased in T1D (p = 0.001) and T2D (p = 0.007) and was associated with cardiac vagal tone (p = 0.03) or glucose (p = 0.04) and haemoglobin A1c (p = 0.005). Ileocaecal pH fall was decreased in T2D (p < 0.001).ConclusionsGastrointestinal function was altered in asymptomatic individuals with diabetes. These findings call for further investigations of gastrointestinal function in order to identify risk factors or even predictors for diabetic enteropathy, particularly when glycaemic control is impaired.© 2021 The Association for the Publication of the Journal of Internal Medicine.

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