• YaowClyve Yu LeonCYLYong Loo Lin School of Medicine, National University of Singapore, Singapore, 10 Medical Dr, Singapore 117597, Singapore., TeohSeth EnSEYong Loo Lin School of Medicine, National University of Singapore, Singapore, 10 Medical Dr, Singapore 117597, Singapore., LimWei ShyannWSYong Loo Lin School of Medicine, National University of Singapore, Singapore, 10 Medical Dr, Singapore 117597, Singapore., WangRenaeta Shi QiRSQYong Loo Lin School of Medicine, National University of Singapore, Singapore, 10 Medical Dr, Singapore 117597, Singapore., HanMing XuanMXDepartment of Community Emergency Health and Paramedic Practice, Monash University, Melbourne, Australia, Building H McMahons Road, Frankston, Vic 3199, Australia., Pin Pin Pek, Benjamin Yong-Qiang Tan, OngMarcus Eng HockMEHDepartment of Emergency Medicine, Singapore General Hospital, Singapore; Health Services & Systems Research, Singapore, 1 Outram Rd, Singapore 169608, Singapore; Duke-NUS Medical School, 8 College Rd, Singapore 169857, Singapore., Qin Xiang Ng, and HoAndrew Fu WahAFWDepartment of Emergency Medicine, Singapore General Hospital, Singapore; Pre-hospital and Emergency Research Centre, 1 Outram Rd, Singapore 169608, Singapore; Duke-NUS Medical School, 8 College Rd, Singapore 169857, Singapore. Electronic.
• Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 10 Medical Dr, Singapore 117597, Singapore.
• Resuscitation. 2022 Jan 1; 170: 82-91.

AimQuality of life after surviving out-of-hospital cardiac arrest (OHCA) is poorly understood, and the risk to mental health is not well understood. We aimed to estimate the prevalence of anxiety, depression, and post-traumatic stress disorder (PTSD) following OHCA.MethodsIn this systematic review and meta-analysis, databases (MEDLINE, EMBASE, and PsycINFO) were searched from inception to July 3, 2021, for studies reporting the prevalence of depression, anxiety, and PTSD among OHCA survivors. Data abstraction and quality assessment were conducted by two authors independently, and a third resolved discrepancies. A single-arm meta-analysis of proportions was conducted to pool the proportion of patients with these conditions at the earliest follow-up time point in each study and at predefined time points. Meta-regression was performed to identify significant moderators that contributed to between-study heterogeneity.ResultsThe search yielded 15,366 articles. 13 articles were included for analysis, which comprised 186,160 patients. The pooled overall prevalence at the earliest time point of follow-up was 19.0% (11 studies; 95% confidence interval [CI] = 11.0-30.0%) for depression, 26.0% (nine studies; 95% CI = 16.0-39.0%) for anxiety, and 20.0% (three studies; 95% CI = 3.0-65.0%) for PTSD. Meta-regression showed that the age of patients and proportion of female sex were non-significant moderators.ConclusionThe burden of mental health disorders is high among survivors of OHCA. There is an urgent need to understand the predisposing risk factors and develop preventive strategies.Copyright © 2021 Elsevier B.V. All rights reserved.

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