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- Małgorzata Kowalska, Ewa Niewiadomska, Kamil Barański, Angelina Kaleta-Pilarska, Grzegorz Brożek, and Jan Eugeniusz Zejda.
- Department of Epidemiology, School of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland.
- Vaccines (Basel). 2021 Apr 21; 9 (5).
AbstractThe explanation of the potential interaction between the influenza vaccine and SARS-CoV-2 infection is urgently needed in the public health. The objective of the study is to compare the occurrence of positive SARS-CoV-2 IgG and IgM tests in subjects with and without recent (last year) seasonal influenza vaccinations. In a cross-sectional study located in three large towns of Silesian Voivodeship (Poland), we studied 5479 subjects in which 1253 (22.9%) had a positive anti-SARS-CoV-2 IgG test and 400 (7.3%) had a positive anti-SARS-CoV-2 IgM test. Seasonal influenza vaccination remains an independent factor protecting against positive IgG tests (OR = 0.68; 0.55-0.83). The effect is not apparent with IgM antibodies. The obtained results confirmed that the serological status of SARS-CoV-2 infection depends on vaccination against seasonal influenza.
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