• Rheumatol. Int. · Nov 2019

    Observational Study

    LAUDES Study: impact of digital ulcers on hand functional limitation, work productivity and daily activities, in systemic sclerosis patients.

    • Ivan Castellví, Saioa Eguiluz, Alejandro Escudero-Contreras, Juan José Ríos, Jaime Calvo-Alén, José Luis Callejas-Rubio, Carlos De la Puente, Carmen Pilar Simeón, Francisco Javier Narváez, Gerard Espinosa, Patricia E Carreira, Manuel Rubio-Rivas, Juan José Alegre, Alfredo Guillén-Del-Castillo, Jose Andrés Román-Ivorra, Vicent Fonollosa, and LAUDES Study Group.
    • Unitat de Reumatologia, Hospital de la Santa Creu i Sant Pau, Carrer de Sant Quintí, 89, 08026, Barcelona, Spain. icastellvi@santpau.cat.
    • Rheumatol. Int. 2019 Nov 1; 39 (11): 1875-1882.

    AbstractThe objective of this study was to evaluate the impact of digital ulcers (DUs) in daily life of systemic sclerosis (SSc) Spanish patients. We developed a multicenter observational study to compare functional disability in SSc patients with active DUs vs. those without DUs. An additional correlation between perception of patients and physicians on disability due to DUs was performed. A total of 199 patients were enrolled, 70 (35%) with DUs. Patients with DUs were younger (48 vs. 58 years; p < 0.001) and had more frequently the diffuse subtype of SSc (45 vs. 24%; p = 0.004) than patients without DUs. Patients with DUs showed significantly higher scores in the Cochin Hand Function Scale overall (p < 0.002) and for each of its five dimensions. They also showed higher scores in the Systemic Sclerosis Health Assessment Questionnaire items related to hand function such as, dress and self-care (p < 0.013), eat (p < 0.013) and grip (p < 0.03), and higher Visual Analogic Scale scores for pain (p < 0.013), trouble related with Raynaud's Phenomenon (p < 0.001) and sense of severity (p < 0.004). Impact on daily activities was significantly higher in patients with DUs (p = 0.002), with a non-significant trend to experience higher impact on work productivity (p = 0.07). A high correlation was found between DUs patients and physicians opinion on the impact of DUs (daily life: Pearson R = 0.86; work productivity: Pearson R = 0.87). Study findings show an impaired hand function and increased disability for daily life activities and work productivity in SSc patients with DUs compared with patients without DUs in Spanish population.

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