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- Yuki Mitarai, Kazuhisa Nakashima, Shohei Fukunaga, Noriyoshi Ishikawa, Takafumi Ito, Yukari Tsubata, and Takeshi Isobe.
- Department of Respiratory Medicine, National Hospital Organization Hamada Medical Center, Japan.
- Intern. Med. 2022 Jul 1; 61 (13): 2013-2017.
AbstractA 70-year-old man received pembrolizumab as a second-line treatment for squamous cell lung cancer of the lower right lobe. After three courses, proteinuria and hematuria were observed, which worsened after seven courses. He was diagnosed with a combination of IgA nephropathy and active interstitial nephritis. Steroid pulse therapy was started, and the dose of prednisolone was gradually reduced from 60 mg/day. Renal dysfunction as an immune-related adverse event of pembrolizumab monotherapy for non-small cell lung cancer has been reported previously. Therefore, establishing a system for the early detection and treatment that distinguishes immune-related glomerular diseases is essential.
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