• Internal medicine · Jul 2022

    Case Reports

    Percutaneous Left Atrial Appendage Closure in a Patient with Diffuse Alveolar Hemorrhaging Associated with Anticoagulant Therapy and Atrial Fibrillation: A Case Report.

    • Takaaki Ogoshi, Masato Fukunaga, Yu Suzuki, Yusuke Taura, and Kazuhiro Yatera.
    • Department of Respiratory, Kokura Memorial Hospital, Japan.
    • Intern. Med. 2022 Jul 1; 61 (13): 2045-2050.

    AbstractDiffuse alveolar hemorrhaging (DAH) due to oral anticoagulation (OAC) is a life-threatening condition that leads to severe respiratory failure. There is a clinical dilemma in that OAC-induced DAH often forces the discontinuation of OAC therapy and the administration of high-dose corticosteroids, which increases the risk of stroke and cardiovascular events. We herein report the first case of OAC-induced DAH and atrial fibrillation (AF) in a patient who completely discontinued OAC therapy and high-dose corticosteroids after experiencing percutaneous left atrial appendage (LAA) occlusion. This case suggests that percutaneous LAA closure may aid in the management of OAC-induced DAH and AF.

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