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Dtsch. Med. Wochenschr. · Feb 1993
Comparative Study[Pulsatile insulin secretion into the portal vein in liver cirrhosis].
- M J Storch, M Rössle, and L Kerp.
- Abteilung Endokrinologie, Medizinische Universitätsklinik Freiburg.
- Dtsch. Med. Wochenschr. 1993 Feb 5; 118 (5): 134-8.
AbstractTo characterize the pulsatile liberation of pancreatic hormones, blood was taken from the portal vein of four patients (three men, one woman; aged 65-71 years) with alcoholic (n = 3) or posthepatitic (n = 1) liver cirrhosis. The concentrations of glucose, insulin, C-peptide and glucagon were measured within one minute. The concentrations of insulin, C-peptide and glucagon varied considerably in intervals of 4.1-6.5 min. The swings in insulin concentration ranged between 17 and 163.5 microU/ml. Oral glucose loading with 100 g increased the insulin and C-peptide swings, but not their periodicity. This indicates that pulsatile insulin secretion is amplitude not rate driven.
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