• Semergen · Nov 2019

    Review

    [Update in the pharmacological treatment of neuropathic pain].

    • A Alcántara Montero, P J Ibor Vidal, A Alonso Verdugo, and E Trillo Calvo.
    • Centro de Salud Manuel Encinas, Consultorio de Malpartida de Cáceres, Cáceres, España; Grupo de Trabajo de Dolor de SEMERGEN. Electronic address: a.alcantara.montero@hotmail.com.
    • Semergen. 2019 Nov 1; 45 (8): 535-545.

    AbstractWe provide an updated review of the pharmacological treatment of neuropathic pain, with emphasis on the latest evidence-based recommendations. Drugs proposed as first line include tricyclic antidepressants (particularly amitriptyline), serotonin-noradrenaline reuptake inhibitors (particularly duloxetine), pregabalin and gabapentin. Second-line treatments include 5% lidocaine medicated plasters and capsaicin 8% patches, only for peripheral neuropathic pain and tramadol; whereas potent opioids and botulinum toxin A (for peripheral neuropathic pain) are considered third-line treatments. Future perspectives include the development of new drugs and a more personalised therapeutic approach, which is made possible by recent progress in the assessment and understanding of neuropathic pain.Copyright © 2019 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

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