• Luis E Tollinche, Kenneth P Seier, Gloria Yang, Kay See Tan, Yekaterina D Tayban, Stephen M Pastores, Cindy B Yeoh, and Kunal Karamchandani.
• Department of Anesthesiology, MetroHealth Medical Center, USA. Electronic address: ltollinche@metrohealth.org.
• J Crit Care. 2022 Apr 1; 68: 162116-21.

PurposeTo estimate the incidence of new prescription of enteral opioids on hospital discharge in opioid naïve, non-surgical, critically ill patients and evaluate the risk factors associated with such occurrence.MethodsUsing hospital-wide and ICU databases, we retrospectively identified all patients (≥ 18 years old) who were admitted to the 20-bed adult ICU of Memorial Sloan Kettering Cancer Center (MSKCC) between July 1, 2015 and April 20, 2020. Patients' electronic medical records (EMR) were retrieved and patient demographics, peri-ICU admission data were captured and analyzed.ResultsDuring the study period, a total of 3755 opioid naïve patients were admitted to the ICU and 848 patients met the inclusion criteria. Among these, 346 (40.8%) patients were discharged with a new opioid prescription. Age at ICU admission, preadmission use of benzodiazepine, and antidepressants, a diagnosis of sepsis, and use of mechanical ventilation, antidepressants or, opioid infusion for greater than 4 h during the ICU stay, hospital length of stay (LOS), and days between ICU discharge and hospital discharge were independently associated with increased odds of a new opioid prescription.ConclusionsA significant proportion of opioid naïve non-surgical ICU survivors receive a new opioid prescription on hospital discharge.Copyright © 2021. Published by Elsevier Inc.

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