• Ahmed Youssef Ali Amer, Femke Wouters, Julie Vranken, de Korte-de BoerDianneDDepartment of Anesthesiology and Pain Management, Maastricht UMC+, 6229 HX Maastricht, The Netherlands., Valérie Smit-Fun, Patrick Duflot, Marie-Hélène Beaupain, Pieter Vandervoort, Stijn Luca, Jean-Marie Aerts, and Bart Vanrumste.
• E-MEDIA, STADIUS, Department of Electrical Engineering (ESAT), Campus Group T, KU Leuven, 3000 Leuven, Belgium.
• Sensors (Basel). 2020 Nov 18; 20 (22).

AbstractIn this prospective, interventional, international study, we investigate continuous monitoring of hospitalised patients' vital signs using wearable technology as a basis for real-time early warning scores (EWS) estimation and vital signs time-series prediction. The collected continuous monitored vital signs are heart rate, blood pressure, respiration rate, and oxygen saturation of a heterogeneous patient population hospitalised in cardiology, postsurgical, and dialysis wards. Two aspects are elaborated in this study. The first is the high-rate (every minute) estimation of the statistical values (e.g., minimum and mean) of the vital signs components of the EWS for one-minute segments in contrast with the conventional routine of 2 to 3 times per day. The second aspect explores the use of a hybrid machine learning algorithm of kNN-LS-SVM for predicting future values of monitored vital signs. It is demonstrated that a real-time implementation of EWS in clinical practice is possible. Furthermore, we showed a promising prediction performance of vital signs compared to the most recent state of the art of a boosted approach of LSTM. The reported mean absolute percentage errors of predicting one-hour averaged heart rate are 4.1, 4.5, and 5% for the upcoming one, two, and three hours respectively for cardiology patients. The obtained results in this study show the potential of using wearable technology to continuously monitor the vital signs of hospitalised patients as the real-time estimation of EWS in addition to a reliable prediction of the future values of these vital signs is presented. Ultimately, both approaches of high-rate EWS computation and vital signs time-series prediction is promising to provide efficient cost-utility, ease of mobility and portability, streaming analytics, and early warning for vital signs deterioration.

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