• J. Endocrinol. · Sep 2003

    Glucocorticoid action and novel mechanisms of steroid resistance: role of glucocorticoid receptor-interacting proteins for glucocorticoid responsiveness.

    • A-C Wikström.
    • Department of Medical Nutrition, Karolinska Institutet, Novum, S-141 86 Huddinge, Sweden. lotta.wikstrom@mednut.ki.se
    • J. Endocrinol. 2003 Sep 1; 178 (3): 331-7.

    AbstractGlucocorticoids are widely used to treat inflammatory and malignant diseases. However, many individuals show a lack of therapeutic response and unwanted side-effects. Various known and unknown parameters determine glucocorticoid responsiveness, among them glucocorticoid receptor (GR)-interacting proteins. Several of the proteins interacting with GR also participate in other signal transduction pathways such as the AP-1 pathway and the nuclear factor-kappaB pathway. We suggest that a closer study of GR-interacting proteins may shed new light on mechanisms determining glucocorticoid sensitivity. In this commentary, the general mechanisms of GR action will be addressed and a proteomic-based method to study GR-interacting proteins will be described in brief.

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