• Primary care · Dec 2017

    Review

    Celiac Disease and Gluten Sensitivity.

    • Katharine C DeGeorge, Jeanetta W Frye, Kim M Stein, Lisa K Rollins, and Daniel F McCarter.
    • Department of Family Medicine, University of Virginia, PO Box 800729, Charlottesville, VA 22908-0543, USA. Electronic address: kd6fp@virginia.edu.
    • Prim. Care. 2017 Dec 1; 44 (4): 693-707.

    AbstractCeliac disease is an immune-mediated enteropathy triggered by gluten that affects genetically predisposed individuals, typically causing intestinal symptoms and malabsorption. Diagnosis requires stepwise evaluation with anti-tissue transglutaminase IgA and histologic analysis of the small bowel. Strict adherence to a gluten-free diet is the primary treatment. Patients with symptoms thought to be related to gluten but without evidence of celiac disease are difficult to diagnose and treat. Consider first advising general nutritional improvements. If symptoms persist, involve a trained dietitian for restrictive diets and consider evaluation for small intestinal bacterial overgrowth or other treatments for irritable bowel syndrome.Copyright © 2017 Elsevier Inc. All rights reserved.

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