• Mt. Sinai J. Med. · Mar 2008

    Review

    Neurotherapeutics in multiple sclerosis: novel agents and emerging treatment strategies.

    • Tracy DeAngelis and Fred Lublin.
    • Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA. tracy.deangelis@mssm.edu
    • Mt. Sinai J. Med. 2008 Mar 1; 75 (2): 157-67.

    AbstractNew insights into the complex immunopathogenesis of multiple sclerosis have led to a proliferation of promising new therapeutic strategies. While the current armamentarium of immunomodulatory medications has demonstrated beneficial effects on the disease, more effective and tolerable therapies are needed. Several novel therapeutic strategies under investigation include oral therapies, monoclonal antibodies, symptomatic treatments, insights into neuroprotection and repair as well as combination regimens. New therapies may prove more efficacious and tolerable than the available arsenal of treatments; however, decisions regarding first-line therapies will expectedly become more complicated, with greater influence if risk-to-benefit ratios in light of premature safety data. Biomarker profiles may help elucidate disease subtypes as well as therapeutic response in an effort to individualize treatment choice. This review will highlight recent promising therapeutic strategies under investigation in the field of MS.Copyright (c) 2008 Mount Sinai School of Medicine

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