• A A Akinbodewa, A Ogunleye, O A Adejumo, V O Daomi, O Okunola, T T Oluwafemi, E O Alli, V O Olalusi, P O Osho, O A Lamidi, F Fadipe, and O K Falekulo.
• Department of Medicine, University of Medical Sciences Teaching Hospital, Ondo, Nigeria.
• Niger J Clin Pract. 2019 Feb 1; 22 (2): 201207201-207.

BackgroundAlthough sickle cell disease has become a recognized etiology of chronic kidney disease (CKD), the sickle cell trait (SCT) variant was until recently believed to be a benign carrier state with little or no effect on the health of affected individuals. However, recent studies now appear to suggest an association between SCT and CKD.ObjectiveThe objective of the study is to determine the association between SCT (hemoglobin AS) and renal dysfunction among young Nigerian adults.MethodologyThis was a cross-sectional, descriptive study among apparently healthy undergraduates of Adeyemi College of Education, Ondo, southwest Nigeria. Their hemoglobin genotypes were determined using standard alkaline electrophoresis; their blood pressure, anthropometry, serum total cholesterol (TC), creatinine, and estimated glomerular filtration rate (eGFR) were determined. Data analyzed using Statistical Package for Social Sciences (SPSS) 20 were significant at P < 0.05.ResultsSix hundred and two subjects with HbAS (SCT, n = 465) and HbAA (non-SCT, n = 137) were studied. Their age range was 18-30 years with male-to-female ratio 1:3.8. There was no difference in the prevalence of renal dysfunction between SCT and non-SCT subjects (5.1% vs. 5.2%, P = 0.591). There was no increased risk of CKD among subjects with SCT (PR, 0.99 at 95% CI [0.417-2.348]).ConclusionSCT was not associated with increased risk of renal dysfunction among young adults in Nigeria. Further studies are needed to clarify the controversy, especially in Nigeria, with a relatively higher prevalence of SCT.

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