• Neil E Wilson, Brian L Burns, Zohaib Iqbal, and M Albert Thomas.
• Department of Radiological Sciences, University of California Los Angeles, Los Angeles, California, USA.
• Magn Reson Med. 2015 Nov 1; 74 (5): 1199-208.

PurposeTo implement a 5D (three spatial + two spectral) correlated spectroscopic imaging sequence for application to human calf.Theory And MethodsNonuniform sampling was applied across the two phase encoded dimensions and the indirect spectral dimension of an echo planar-correlated spectroscopic imaging sequence. Reconstruction was applied that minimized the group sparse mixed ℓ2,1-norm of the data. Multichannel data were compressed using a sensitivity map-based approach with a spatially dependent transform matrix and utilized the self-sparsity of the individual coil images to simplify the reconstruction.ResultsSingle channel data with 8× and 16× undersampling are shown in the calf of a diabetic patient. A 15-channel scan with 12× undersampling of a healthy volunteer was reconstructed using 5 virtual channels and compared to a fully sampled single slice scan. Group sparse reconstruction faithfully reconstructs the lipid cross peaks much better than ℓ1 minimization.ConclusionCOSY spectra can be acquired over a 3D spatial volume with scan time under 15 min using echo planar readout with highly undersampled data and group sparse reconstruction.© 2015 Wiley Periodicals, Inc.

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