• Aynur Amanzholkyzy, Rose E Nurgalieva, Arystan Zh Dosimov, Edgaras Stankevicius, and Ayman T Kaldybaeva.
• West Kazakhstan Marat Ospanov State Medical University, 030000, Maresiev Street 68, Aktobe, Kazakhstan. Electronic address: aynur.amanzholkyzy@yandex.ru.
• J Natl Med Assoc. 2018 Feb 1; 110 (1): 78-83.

Background (Objectives)The objective of the article is studying the connection of VDR gene polymorphisms with bone tissue mineral density and biochemical marker of 25-PO vitamin D in adolescents of both ethnic groups, living in Western Kazakhstan Region.MethodsThe study included 110 relatively healthy children aged 13-18 years of Aktobe, the representatives of Kazakh ethnic group e 66 (Kazakh children) and Slavonic e 44 (Russian children). The groups were formed according to BTMD data, ethnic affiliation and according to content of vitamin D and gene polymorphism of vitamin D (VDR).ResultsGenotype SS is negative marker in Kazakh adolescents of Western Kazakhstan Region for BTMD and 25-PO vitamin D; in children of Kazakh nationality with osteopathy sign, genotype SS occurs at almost twice the rate in comparison with Slavonic ethnic group and respectively by a factor of 2 less 25-PO vitamin D content.ConclusionDisorders of bone mineralization and metabolism depend on ethnic affiliation and presence of defined polymorphic genotypes of VDR gene molecular markers. Genotype Tt is a normal variant of gene polymorphism and is characterized by significantly less 25-PO vitamin D content in adolescents of Kazakh ethnic group, in comparison with their age mates of Slavonic ethnic group.Copyright © 2018 National Medical Association. Published by Elsevier Inc. All rights reserved.

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