• Dtsch. Med. Wochenschr. · Aug 2018

    [Infusion of Daratumumab in Combination Therapies - Practical Information for The Outpatient Area].

    • Christof Scheid, Markus Munder, Hans Salwender, and Monika Engelhardt.
    • Dtsch. Med. Wochenschr. 2018 Aug 1; 143 (16): 1201-1206.

    AbstractCombination therapies such as Dara-Rd and Dara-Vd show significantly higher survival rates after 12 months than the respective therapies without Daratumumab. The initial infusion of Daratumumab is associated with a high incidence of IRR. Dosage and speed of infusion of Daratumumab have to be strictly controlled. Any suspicion of even low IRR requires corrections. Concomitant medication before and after Daratumumab administration is required. For this purpose, various preparations have been tested in everyday clinical practice. Eight hours of infusion may be required. This does not only overwhelm the patient, but also the most ambulant structures. The split-dose concept means to divide the dose into infusions on different days. Again, the dosage is crucial for good compatibility.© Georg Thieme Verlag KG Stuttgart · New York.

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