• Knut Kröger, Christine Espinola-Klein, Ulrich Hoffmann, Christoph Kalka, Holger Lawall, and Norbert Weiss.
• Klinik für Gefäßmedizin, HELIOS Klinik Krefeld.
• Dtsch. Med. Wochenschr. 2018 Sep 1; 143 (19): 1391-1396.

AbstractThe guideline of the European Society of Cardiology recommends an LDL-C target < 70 mg/dL or a 50 % reduction in patients with manifest peripheral arterial disease (PAD) as well as in CHD or cerebrovascular disease when the baseline LDL-C is between 70 and 135 mg/dL. Application of a PCSK9 inhibitor allows target attainment for those patients who do not achieve this under maximal conventional therapy with a statin in combination with ezetemib. In the Fourier study, patients with PAOD who had neither a myocardial infarction nor a stroke at admission of the study had a significant risk reduction (RR) of both cardiovascular (RR = 0.67, 0.47 - 0.96, p = 0.0283) as well as extremity endpoints (RR = 0.43 (0.19 - 0.99; p = 0.042). In Germany these patients are primarily seen by angiologists. This group of vascular specialists is specifically mentioned in the decision of the Federal Joint Committee as one of those who may indicate treatment with PCSK9 inhibitors.© Georg Thieme Verlag KG Stuttgart · New York.

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