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Editorial Comment
Sex hormones and the young brain: are we ready to embrace neuroprotective strategies?
- Vesna Jevtovic-Todorovic.
- Department of Anaesthesiology, School of Medicine, University of Colorado, Aurora, CO, USA. Electronic address: vesna.jevtovic-todorovic@cuanschutz.edu.
- Br J Anaesth. 2022 Feb 1; 128 (2): 229-231.
AbstractGrowing animal and clinical data continue to point to general anaesthetics as being potentially detrimental to the very young brain. While we are trying to understand the mechanisms responsible for this worrisome phenomenon, we must consider the value of protective strategies that would enable use of currently available general anaesthetics while avoiding histopathological changes and long-lasting impairment in behavioural and cognitive development. Wali and colleagues1 report that the gestational hormone progesterone is a promising 'safening' agent that ameliorates systemic inflammation caused by sevoflurane, a commonly used inhaled anaesthetic, while preventing development of cognitive impairment and an anxious phenotype.Copyright © 2021 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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