• Tomohiko Urano, Ken'ichiro Narusawa, Masataka Shiraki, Takahiko Usui, Noriko Sasaki, Takayuki Hosoi, Yasuyoshi Ouchi, Toshitaka Nakamura, and Satoshi Inoue.
• Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
• Spine. 2008 May 15; 33 (11): 125612611256-61.

Study DesignAn association study investigating the genetic etiology for spinal disc degeneration.ObjectiveTo determine the association of single-nucleotide polymorphism (SNP) in the insulin-like growth factor-1 receptor (IGF1R) with spinal disc degeneration.Summary Of Background DataInsulin-like growth factor-1 (IGF-1) signaling pathway is involved in cartilage development and homeostasis, suggesting that genetic variations of genes involved in this pathway may affect the pathogenesis of cartilage-related diseases, such as disc degeneration.MethodsWe evaluated the presence of endplate sclerosis, osteophytes, and narrowing of disc spaces in 434 Japanese postmenopausal women. A SNP in the IGF1R gene at intron 1 was determined using TaqMan polymerase chain reaction method.ResultsWe compared those who carried the G allele (GG or GC, n = 290) with those who did not (CC, n = 144). We found that the subjects with the G allele (GG or GC) were significantly over-represented in the subjects having higher disc narrowing score (P = 0.0033; odds ratio, 2.04; 95% confidence interval, 1.27-3.29 by logistic regression analysis).ConclusionWe suggest that a genetic variation at the IGF1R gene locus is associated with spinal disc degeneration, in line with the involvement of the IGF1R gene in the cartilage metabolism.

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