• World Neurosurg · Jul 2010

    The Aurora A F31I polymorphism is not a risk factor for glioblastoma.

    • Kapila S Navaratne and Robert J Weil.
    • The Brain Tumor and Neuro-Oncology Center, Department of Neurosurgery and the Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA. kapila_nava@yahoo.com
    • World Neurosurg. 2010 Jul 1; 74 (1): 144-6.

    BackgroundThe Aurora A F31I polymorphism has been linked to increased risk of several human cancers. Glioblastoma (GBM) is the most malignant glioma as well as the most frequent adult primary brain tumor.MethodsIn this case-control study we investigated the association of Aurora A F31I polymorphism with GBM risk.ResultsA total of 96 histologically confirmed patients with GBM and 93 health individuals were analyzed for the Aurora A F31I single nucleotide polymorphism. The single nucleotide polymorphism data were compared and risks associated with individual genotypes and allelotypes were evaluated in terms of odd ratios.ConclusionsThe data obtained from this case-control study demonstrates that the Aurora A F31I polymorphism is not a significant risk for GBMs.Copyright © 2010 Elsevier Inc. All rights reserved.

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