• Ir J Med Sci · Dec 2010

    Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia.

    • K Haslam, N Chadwick, J Kelly, P Browne, E Vandenberghe, C Flynn, E Conneally, and S E Langabeer.
    • Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James Hospital, Dublin, Ireland. khaslam@stjames.ie
    • Ir J Med Sci. 2010 Dec 1; 179 (4): 507-10.

    BackgroundAcute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells. Approximately half of all adult AML patients have a normal karyotype (NK-AML) and an intermediate risk prognosis.AimsTo determine the incidence and prognostic significance of NPM1 and FLT3-ITD mutations in a population of patients with NK-AML.MethodsFLT3-ITD and NPM1 mutation status was retrospectively sought in presentation samples from 44 NK-AML patients.ResultsFLT3-ITD and NPM1 mutations were detected in 45.5 and 54.5% of patients, respectively, allowing stratification according to genotype.ConclusionsFLT3-ITD and NPM1 mutation status can be defined in NK-AML. Prospective screening for these mutations is advocated in all NK-AML patients, as the genotype is of clinical importance when considering treatment options including stem cell transplantation.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…