• J. Investig. Med. · Jan 2019

    Everolimus shows synergistic antimyeloma effects with bortezomib via the AKT/mTOR pathway.

    • Jing Li, Zhaoyun Liu, Yanqi Li, Qian Jing, Honglei Wang, Hui Liu, Jin Chen, Junru Feng, Qing Shao, and Rong Fu.
    • Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.
    • J. Investig. Med. 2019 Jan 1; 67 (1): 39-47.

    AbstractMultiple myeloma (MM) is characterized by the proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraproteins (M proteins). Everolimus works similarly to sirolimus as a mammalian target of rapamycin (mTOR) inhibitor. Bortezomib was the first therapeutic proteasome inhibitor to be tested in humans with MM. However, the combination of these two drugs for the treatment of MM has been rarely reported. In this study, we compared the therapeutic effects of everolimus and bortezomib, as well as those of a combination of everolimus and bortezomib, using an in vitro MM cell line model and in vivo xenograft mouse model. Our results showed that the synergistic antitumor effects of everolimus and bortezomib have significant inhibitory effect through inhibition of the AKT/mTOR pathway in both the MM cell lines and MM-bearing mice model. Our results provided evidence that the mTOR inhibitor, everolimus, will be a potential drug in MM therapy.© American Federation for Medical Research 2019. No commercial re-use. See rights and permissions. Published by BMJ.

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