• J Neurosurg Anesthesiol · Jan 2022

    Insights into Fibrinogen-Mediated COVID-19 Hypercoagubility in Critically Ill Patients.

    • Andrea Miltiades, Philipp J Houck, Matthew Monteleone, Neil L Harrison, David Cabrera-Garcia, David Roh, and Gebhard Wagener.
    • Departments of Anesthesiology.
    • J Neurosurg Anesthesiol. 2022 Jan 1; 34 (1): 136140136-140.

    AbstractCoronavirus disease-2019 (COVID-19) is associated with hypercoagulability that may cause thromobembolic complications. We describe our recent studies investigating the mechanisms of hypercoagulability in patients with severe COVID-19 requiring mechanical ventilation during the COVID-19 crisis in New York City in spring 2020. Using rotational thombelastometry we found that almost all patients with severe COVID-19 had signs of hypercoagulability compared with non-COVID-19 controls. Specifically, the maximal clot firmness in the fibrin-based extrinsically activated test was almost twice the upper limit of normal in COVID patients, indicating a fibrin-mediated cause for hypercoagulability. To better understand the mechanism of this hypercoagulability we measured the components of the fibrinolytic pathways. Fibrinogen, tissue plasminogen activator and plasminogen activator inhibitor-1, but not plasminogen levels were elevated in patients with severe COVID-19. Our studies indicate that hypercoagulability in COVID-19 may be because of decreased fibrinolysis resulting from inhibition of plasmin through high levels of plasminogen activator inhibitor-1. Clinicians creating treatment protocols for anticoagulation in critically ill COVID-19 patients should consider these potential mechanisms of hypercoaguability.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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