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- Sh Erdes, I A Guseva, and L I Benevolenskaia.
- Terapevt Arkh. 2001 Jan 1; 73 (1): 27-30.
AimTo characterize relationship between prevalence of ankylosing spondylarthritis (ASA) and incidence rate of HLA-B27 in genotypically different ethnic groups of Russia with interpolation of the results to other populations.Material And Methods2287 individuals from genotypically different ethnic groups were examined in overall one-stage epidemiological trial.ResultsPrevalence of ASA in ethnic groups ranged from 0.2 to 2.0% while occurrence of HLA0B27--from 15 to 40%. Rate of correlation between the disease prevalence and incidence of B27 was 0.82. The equation for calculation of ASA incidence rate by HLA-B27 incidence was devised: AC(%) = -0.40 + 0.06x.ConclusionIn most world populations prevalence of ASA correlates with population frequency HLA-B27 though in some ethnic groups this correlation is absent. Consequently, ASA is genetically heterogenous.
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