• S V Gritsaev, I S Martynkevich, Zh V Chubukina, E V Petrova, I I Kostroma, M P Ivanova, L S Martynenko, N A Potikhonova, L N Bubnova, and K M Abdulkadyrov.
• Terapevt Arkh. 2014 Jan 1; 86 (3): 71-7.

AimTo study the specific features of de novo acute myeloid leukemia (AML) with FLT3-ITD mutation.Subjects And MethodsThe results of examination were analyzed in 101 patients. Bone marrow morphological specimens were stained with Pappenheim stain. The karyotype was investigated using the standard GTG-banding method. Blast cells were immunotyped in a five-color analysis on a Cytomics FC 500 laser flow cytofluorometer.ResultsFLT3-ITD mutation was identified in 21 patients who had a varying morphological nature of blasts, different karyotype variants, and frequently additional NPM1 gene mutation. The distinctive property of 10 patients with normal karyotype and FLT3-ITD mutation (without NPM1 gene mutation) was the larger number of cases with high expression of HLA-DR and CD7 than in the control group that included 18 patients with normal karyotype AML without FLT3-ITD nutation: 50% versus 6.2% (p = 0.007) and 100% versus 55.6% (p = 0.014), respectively.ConclusionNormal karyotype AML with FLT3-ITD mutation is a group that is homogeneous in the biological phenotype of leukemia cells.

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